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2024-05-02


NCBI Gene Summary for PDE4D Gene. This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively ...

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Introduction. Pancreatic ductal adenocarcinoma (PDAC) is known as one of the most devastating cancer with an extremely poor prognosis. According to the report of GLOBOCAN 2012, there were 65,727 Chinese diagnosed with PDAC, among which 63,662 cases died, accounting for 96.86% of the newly diagnosed PDAC cases in China during 2012 1.PDAC is the fourth leading cause of cancer-related death in ...

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1. Introduction. Impaired memory function in Alzheimer's disease (AD) patients has a debilitating effect on daily activities and, consequently, negatively affects the quality of life of patients, their caretakers, and family (Schneider et al., 1999).The second messenger cyclic adenosine monophosphate (cAMP) is crucial in the molecular signaling cascades underlying memory function (Kandel, 2012).

People encounter Infrared waves every day; the human eye cannot see it, but humans can detect it as heat. A remote control uses light waves just beyond the visible spectrum of light—infrared light waves—to change channels on your TV. This […]

PDE4 upregulation is a late event in many cancer cells preceded by the following steps: (1) A mitogen activates cAMP in cancer cells. (2) cAMP inhibits the PI3K/AKT pathway. (3) Inhibition of the ...

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A growing body of epidemiological evidence suggests that nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for chronic kidney disease (CKD), but the regulatory mechanism ...

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